人才队伍

李拓

信息来源: 发布日期:2025-05-17

个人简历

姓 名

李拓

专 业

天然产物化学/合成生物学

学历学位

博士研究生/药学博士

电子邮箱

lituo@dlu.edu.cn

研究方向

海洋古菌膜脂与萜类的合成生物学研究


学术成果



1, Bioactivity guided isolation of anticancer constituents fromHedera nepalensisK. Koch.

Tuo. Li, H. Pan, Y. Feng, H, Li, Y. Zhao. South Africa Journal of Botany. 2015, 100, 87-93.

2, Identification of α-glucosidase inhibitors inMachilus litseifoliaby combined use of high-resolutionα-glucosidase inhibition profiling and HPLC-PDA-HRMS-SPE-NMR.

Tuo Li, Kenneth T. Kongstad, and Dan Staerk. Journal of Natural Products. 2019, 82, 249-258.

3, Antidiabetic constituents ofDendrobium officinaleas determined by high-resolution profiling of radical scavenging andα-glucosidase andα-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.

Chu Chu,Tuo Li, Hans Albert Pedersen, Kenneth T. Kongstad, Jizhong Yan, Dan Staerk. Phytochemistry Letters. 2019, 31, 47-52.

4, Combined magnetic ligand fishing and high-resolution inhibition profiling for identification ofα-glucosidase inhibitory ligands: A new screening approach based on complimentary inhibition and affinity profiles.

Sileshi G. Wubshet, Bingrui Liu, Kenneth T. Kongstad, Ulrike Böcker, Malene J. Petersen,Tuo Li, Junru Wang, Dan Staerk. Talanta 200 (2019) 279–287.

5, Structure Elucidation of Prenyl- and Geranyl-Substituted Coumarins inGerbera piloselloidesby NMR Spectroscopy, Electronic Circular Dichroism Calculations, and Single Crystal X-ray Crystallography

Tuo Li, Xue Ma, Daniil Fedotov, Louise Kjaerul, Karla Frydenvang, Sonia Coriani, Paul Robert Hansen, Kenneth T. Kongstad and Dan Staerk. Molecules 2020, 25, 1706.

6,基于合成生物学策略的酶蛋白元件规模化挖掘,

张建志,付立豪,唐婷,张嵩亚,朱静,李拓,王子宁,司同.合成生物学, 2020,1,(3): 319-336.

7, Anti-bacterial mechanism of the P-3 against Aeromonas hydrophila NJ-35 extracted from thePotentilla chinensisSer. (Wei Ling Cai)

Zhenzhen Li, Lili He, Liren He, Fuxing Chen, Suquan Song, Hang Zhang, Weidong Sun, Xiaowei Bao, Haibin Zhang,Tuo Li, Chenghua He, Aquaculture 541 (2021) 736746.

8, Biosynthesis of Hybrid Neutral Lipids with Archaeal and Eukaryotic Characteristics in EngineeredSaccharomyces cerevisiae.

Jianzhi Zhang,Tuo Li, Zhilai Hong, Chenfei Ma, Xiaoting Fang, Fengfeng Zheng, Wenkai Teng, Chuanlun Zhang, and Tong Si. Angewandte Chemie, 14 Dec 2022, 62(4):e202214344.

9, Polypharmacology-Labeled Molecular Networking: An Analytical Technology Workflow for Accelerated Identification of Multiple Bioactive Constituents in Complex Extracts.

Yong Zhao, Oliver Gericke,Tuo Li, Louise Kjaerulff, Kenneth T. Kongstad, Allison Heskes, Birger L. Møller, Flemming S. Jørgensen, Henrietta Venter, Sonia Coriani, Susan J. Semple, and Dan Staerk, Analytical Chemistry, 2023, 95, 9, 4381–4389

10, Orthogonal Reversed-Phase C18 and Pentafluorophenyl HPLC Separation for Phytochemical Profiling of Serrulatanes inEremophila denticulate.

Yong Zhao,Tuo Li, Louise Kjaerulff, Henrietta Venter, Sonia Coriani, Birger Lindberg Møller, Susan Semple, and Dan Staerk. Journal of Natural Products. 2023, 86, 12, 2638–2650

11, Two-phase Fermentation Systems for Microbial Production of Plant-Derived Terpenes.

Tuo Li, Ximeng Liu, Haoyu Xiang, Hehua Zhu, Xuan Lu, and Baomin Feng. Molecules. 2024, 29, 1127.


参与课题项目



1、阿斯加德(Asgard)古菌细胞膜磷脂合成酶GGGPS底物选择性研究,国家自然科学基金青年基金(32201201),30万元,主持

2、β-榄香烯工程菌株构建及关键合酶的研究,大连大学科研平台校内基金(202301YB04),5万元,主持

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