个人简历

姓 名

马逍遥

专 业

化学生物学

学历学位

博士研究生/理学博士

电子邮箱

mxy83396376@163.com

研究方向

中药药效物质基础与作用机制研究

代表论文：

[1]Xiaoyao Ma¹, Jinling Zhang¹, Ge Fang, He Gao, Jie Gao*, Li Fu*, Yuanyuan Hou*, Gang Bai. Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect.Chinese Chemical Letters. 2024, 35(5): 108823.

[2]Xiaoyao Ma, Yiman Han, Kaixin Liu, Yongping Bai, He Gao, Yuanyuan Hou*, Gang Bai*. Chemical proteomics combined with metabonomics reveals that berberine targets NDUFV1 of Complex I in the respiratory chain to regulate energy metabolism.Chinese Chemical Letters. 2023, 34(3): 107595.

[3]Xiaoyao Ma, Yongping Bai, Kaixin Liu, Yiman Han, Jinling Zhang, Yuteng Liu, Xiaotao Hou, Erwei Hao*, Yuanyuan Hou*, Gang Bai*. Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1in vivo.Phytomedicine,2022, 103: 154233.

[4]Xiaoyao Ma, Man Zhang, Ge Fang, Chuanjing Cheng, Mukuo Wang, Yiman Han, Xiaotao Hou, Erwei Hao, Yuanyuan Hou*, Gang Bai. Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3in vivo.Acta Pharmacologica Sinica,2021,42(7): 1101-1110.

[5]Xiaoyao Ma, Kaixin Liu, Yiman Han, Yongping Bai, Fukui Shen, Mukuo Wang, Wei Wei, Jianfeng Qin, Erwei Hao, Xiaotao Hou*, Yuanyuan Hou*, Gang Bai*. Cinnamaldehyde regulates the generation of��-aminobutyric acid to exert sedation via irreversible inhibition of ENO1 in the cerebellar granular layer.Molecular Nutrition & Food Research,2022, 66(11): e2100963.

[6]Xiaoyao Ma, Aina Liu, Wenjuan Liu, Zhihua Wang, Nianwei Chang, Sunyun Li, Jiansheng Li, Yuanyuan Hou*, Gang Bai*. Analyze and identify peiminine target EGFR improve lung function and alleviate pulmonary fibrosis to prevent exacerbation of chronic obstructive pulmonary disease by phosphoproteomics analysis.Frontiers in Pharmacology,2019, 10:737.

[7]XiaoyaoMa, Yuan Zhang, Zengyong Wang, Yuebing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou*, Gang Bai*. Ursolic acid, a natural nutraceutical agent, targets caspase3 and alleviates inflammation-associated downstream signal transduction.Molecular Nutrition & Food Research, 2017, 61(12): 1700332.

[8] Mengru Zhou¹,Xiaoyao Ma¹, Jiaqi Zhang, Xuan Lu*. 3,5-Dimethyl-8-methoxy-3,4-dihydro1Hisochromen-6-ol Attenuates Ulcerative Colitis via Targeting NLRP3 in Mice.Journal of Agricultural and Food Chemistry,2024, 72(30): 16700-16707.

参与课题项目

[1]国家自然科学基金委员会,青年项目,82304699，基于线粒体复合物I的黄连清热药效物质基础与分子机制研究（2024.1-2026.12），主持。

[2]中国博士后科学基金，第68批面上项目，2020M680871，小檗碱与其清热靶点Ndufv1的相互作用关系研究 （2021.1-2022.12），主持。

[3]国家自然科学基金委员会,面上项目,81973449，基于氧化呼吸链的中医清热的化学物质基础及其生物学机制研究，参与。

[4]国家自然科学基金委员会，国际(地区)合作与交流项目，81761168039，桔梗“引药上行”药效物质基础的作用机理及配伍应用的化学生物学研究，参与。

[5]国家自然科学基金委员会，面上项目，81673616，清热解毒核心药对调节免疫配伍相须的分子机制研究，参与。