个人简历

姓 名

卢玉杰

专 业

药物分析学

学历学位

博士研究生/工学博士

电子邮箱

luyujie1227@126.com

研究方向

基于化学生物学的活性天然产物作用靶点、与靶点间结合模式以及发挥活性的生物学机制研究

(1)Yujie Lu; Lin Niu; Fukui Shen; Wen Yang; Yang Xie; Suyun Li; Min Jiang; Gang Bai ; Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3‐SARA interaction, Phytotherapy Research, 2023, 37(2): 717-730.

(2)Yujie Lu; Man Zhang; Jin Zhang; Min Jiang; Gang Bai ; Psoralen prevents the inactivation of estradiol and treats osteoporosis via covalently targeting HSD17B2, Journal of Ethnopharmacology, 2023, 311: 116426.

(3)Yujie Lu; Jie Ji; Simeng Chu; Fukui Shen; Wen Yang; Wei Lei; Min Jiang; Gang Bai ; CaMKII, that binds with ligustilide, as a potential drug target of Suxiao jiuxin pill, a traditional Chinese medicine to dilate thoracic aorta, Clinical and translational medicine, 2022, 12(6): e907.

(4)Yujie Lu; Wenjuan Liu; Man Zhang; YanFang Deng; Min Jiang; Gang Bai ; The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS, Evidence-based Complementary and Alternative Medicine, 2019, 2019: 6150357.

(5)Yujie Lu; Yanfang Deng; Wenjuan Liu; Min Jiang; Gang Bai ; Searching for calcium antagonists for hypertension disease therapy from Moutan Cortex, using bioactivity integrated UHPLC‐QTOF‐MS, Phytochemical Analysis, 2019, 30(4): 456-463.

参与课题项目

(1)基于CaMKII-HMGCS1-Smad3的川芎“行气活血”药效物质基础与分子机制研究,国家青年科学基金项目,82404837,2025-01-01至2027-12-31, 30万元,在研,主持

(2)基于17β-HSD2/CYP450s-GSTs的补骨脂“效毒一体”物质基础及作用机制研究，国家自然科学基金面上项目, 82073980, 2021-01-01至2024-12-31, 55万元,在研,参与

(3)附子直接生物学靶标发现及效-毒平衡的配伍减毒机制研究,国家自然科学基金面上项目, 81873104, 2019-01-01至2022-12-31, 60万元,结题,参与